Pusat Pengajian Sains Asas

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Characterization and mechanistic studies on the synthesis of 1,3,4-thiadiazole derivatives
(Terengganu: Universiti Malaysia Terengganu, 2014-08) Siti Fatimah Abdul Mutalib
The versatile compound of thiourea and a highly biological potential of Sbenzyldithiocarbazate (SBDTC) compound have inspired the production of hybrid compounds which contained both moieties which are thiourea and dithiocarbazate. For this reason, a reaction between acyl chloride, ammonium thiocyanate and SBDTC were reacted to produce the desired thiourea-dithiocarbazate derivatives. However, the desired compound did not obtained from the reaction but gives a heterocyclic compound namely 1,3,4-thiadiazole derivatives.
Characterization of target-site mutation in 5-Enolpyruvylshikimate-3-Phosphate Synthase (EPSPS) gene from glyphosate-resistant biotype of Eleusine indica (L.) gaertn from Malaysia
(Terengganu: Universiti Malaysia Terengganu, 2013-06) Franci Julop
The population of goosegrass (Eleusine indica), resistant to glyphosate (an EPSPS–inhibiting herbicide) was found widespread in several states in Malaysia. However, the resistance levels in this plants which could lead to the understanding of its resistance mechanisms are not well studied. This study was therefore carried out to investigate different levels of resistance of goosegrass to glyphosate by the identification of mutations in the EPSPS gene. Whole plant bioassay confirmed that 9 out of the 20 populations collected were resistant, six populations were susceptible, while five populations were a mixture of resistant and susceptible biotypes.
Corrosion Protection Of Stainless Steel 316l By Incorporating Zinc Oxide-(Poly(3,4-Ethylenedioxythiophene)Poly(Styrenesulfonate), Pedot:Pss) Hybrid Nanocomposite In Epoxy Based Coating For Marine Application
(Universiti Malaysia Terengganu, 2018) Nurul Ain Binti Abdul Rahim
Stainless steel 316L is extensively used in high performance application due to its good mechanical strength and resistance towards corrosion. However, this type of steel is still tends to undergo pitting and crevice corrosion when exposed to aggressive environment such as marine environment. In this study, a new coating material is formulated to control corrosion by introducing zinc oxide (ZnO) and (poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate), PEDOT:PSS) hybrid nanocomposite into epoxy resin based coating. The physiochemical properties of formulated coating and the effect of varied weight percentage (wt.%) of hybrid nanocomposite with immersion time on coating performance is studied. To achieve these objectives, 1 to 5 wt.% ZnO-PEDOT:PSS is mixed and dispersed in epoxy based coating and coated on 316L substrates using brush coating technique. The samples are immersed in real environment for 60 days. The Fourier Transform Infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscope/Energy-Dispersive X-ray spectroscopy (FESEM/EDX), Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD) and Thermo-Gravimetric Analysis (TGA) analysis showed good compatibility and stability between ZnO and PEDOT:PSS in epoxy based coating while maintained amorphous state of epoxy coating.
Cultured marine bacteria isolated from sponges for discovery of bioactive compounds
(Terengganu: Universiti Malaysia Terengganu, 2014) Humairah Mohd Nasir
Association of marine bacteria and sponges was vastly reported since decades ago. Their contribution in the discovery of new bioactive compounds is also not a new issue. Interestingly, structural similarities between the metabolites of the sponge and its associated bacteria, those found within its tissue, indicate that these compounds are of bacterial origin. This study was conducted to isolate and characterize bacteria from marine sponges and to investigate the release of antibacterial compounds from marine isolates under ecologically relevant conditions.
Cytotoxicity, genotoxicity and quatitative structure-activity relationship (QSAR) studies of stnthesized carbonyl thiourea derivatives on acanthamoeba SPP. and human corneal epithelial cel
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Maizatul Akma Ibrahim
Forty-four synthesized carbonyl thiourea derivatives were evaluated for their potential as anti-amoebic agent, aiming for a new discovery in Acanthamoeba keratitis treatment. The compounds were tested on four isolates of Acanthamoeba namely A. castellanii (CCAP 1501/2A), A. polyphaga (CCAP 1501/3A), Acanthamoeba sp. (Hospital Kuala Lumpur isolate) and Acanthamoeba sp. (Setiu Wetland isolate).
Development And Characterization Of Unplasticized And Plasticized Carboxymethyl Cellulose Doped Oleic Acid Solid Bio-Polymer Electrolytes And Its Application In Rechargeable Proton Battery
(Universiti Malaysia Terengganu, 2017-01) Chai Mui Nyuk
In this research, two solid bio-polymer electrolyte (SBE) systems of an unplasticized carboxyl methylcellulose doped with oleic acid (CMC–OA) and a similar system plasticized with Glycerol (CMC–OA–Gly) have been successfully prepared by solution casting technique. Both SBEs system were free-standing, transparent with no phase separation films. Fourier Transform Infrared (FTIR) analysis reveals that complexations have occurred between CMC and OA at 2850 cm -1 -1 , 2920 cm -1 and 1597 cm . No significant complexation was observed with the addition of Gly, hence, Gly has acted as a new pathway which helped in the hopping of H + to other coordinating sites of carboxylate anion (COO¯) moiety in CMC. X–Ray Diffraction (XRD) analysis showed the structure of CMC–OA and CMC–OA–Gly as both amorphous. CMC–OA SBE had crystallinity which increased from 9.35 Å to 11.41 Å upon addition of OA till 20 wt. % of OA (OA–20). With the addition of plasticizer (Gly) into CMC–OA SBE, XRD analysis showed that Gly had increased the amorphousness of the SBEs.
Development of carboxymethyl cellulose based proton conducting biopolymer electrolytes and its application in solid-state proton battery
(Terengganu: Universiti Malaysia Terengganu, 2014-06) Ahmad Salihin Samsudin
The chronicle in the field of alternative energy for energy storage has shown an excellent progress for the past few years. The increasing interest in green energy storage materials with the development of polymer or biopolymer as electrolytes candidate has attracted great attention.
Development of investment casting molds based on Terengganu silica sand for aluminum and copper alloys
(Universiti Malaysia Terengganu, 2017-03) Siti Zaleha Mohd Nor
The research reported in this thesis has four main objectives. These include to investigate the chemical composition and structural properties of Terengganu local silica sand for foundry use, to develop a suitable investment casting mold formulations, to investigate the thermal and mechanical properties of the developed mold and to recommend a suitable formulation and casting procedures for both of aluminium and copper alloy. The study was conducted in two main phases, where the first phase emphasized on the development of Terengganu silica sand as a mold material while the second phase focused on the application of the developed mold in investment casting process. With the silica content more than 97% and Grain Fineness Number (GFN) of 57 and 49, Kuala Abang and Jambu Bongkok silica were found the most appropriate silica as they can be used directly without the need to grind first. Then, using these silica as a refractory material and plaster of paris (POP) as a binder, several formulations were developed. The compositions used were 75% silica, 25% POP and 31 - 37% water. Silica percentage was also varied from 60 - 85% with POP content changing from 15 - 40%.
The effect of ammonium nitrate and ethylene glycol in carboxymethyl cellulose solid polymer electrolytes for rechargeable proton battery
(Terengganu: Universiti Malaysia Terengganu, 2016-02) Khadijah Hilmun Kamarudin
Solid polymer electrolytes (SPEs) have been recognised as promising electrolytes to overcome the limitation in gel/liquid counterparts. In this research, the potential of carboxymethyl cellulose (CMC)-based SPEs was studied.
The Effect Of Ammonium Nitrate And Ethylene Glycol In Carboxymethyl Cellulose Solid Polymer Electrolytes For Rechargeable Proton Battery
(Universiti Malaysia Terengganu, 2016-02) Khadijah Hilmun Kamarudin
Solid polymer electrolytes (SPEs) have been recognised as promising electrolytes to overcome the limitation in gel/liquid counterparts. In this research, the potential of carboxymethyl cellulose (CMC)-based SPEs was studied. Two systems, namely System I which comprised of CMC doped ammonium nitrate (NH4NO3) salt and System II which comprised of CMC-NH4NO3 plasticized ethylene glycol (EG) are prepared via solution casting technique. The interactions between polymer, salt and plasticizer in both systems are observed by FTIR analysis. The amorphousness and thermal behaviour of both systems are obtained by XRD and TGA-DTG analyses, respectively. The incorporation of 45 wt.% NH4NO3 salt in System I has optimized the ambient temperature ionic conductivity to (7.71  0.04) x 10 -3 -1 Scm . Ionic conductivity is enhanced to (3.80  0.06) x 10 -2 -1 Scm on the addition of 20 wt.% EG plasticizer in System II. The temperature-dependent ionic conductivity for both electrolyte systems is Arrhenian and thermally activated.
Effect of chlorphyll on P3TAA, PT and PPY thin films for the fabrication of organic solar cells
(Terengganu: Universiti Malaysia Terengganu, 2015-08) Hamizah Nadia Alias@Yusof
In this project, single layer and double layer organic solar cells were fabricated from multi group organic materials; poly (3-thiophene acetic acid) (P3TAA), polythiophene (PT), polypyrrole (PPY) and chlorophyll (CHLO). Single layer thin films were deposited on indium tin oxide (ITO) coated glass substrate by using electrochemical impedance spectroscopy (EIS) and the second layer, CHLO thin film was deposited on top of conjugated polymers thin film by using spin coater, all at room temperature. Electrical properties and optical properties for both types of organic solar cells were studied and determined by four point probe method, two point probe method, both at dark and under different light intensity, and ultraviolet-visible (UV-Vis) spectroscopy respectively.
Effect of estrogen hormone, 17 B-Estradiol on feminization, survival and growth of banana shrimp, Fenneropenaeus merguiensis (De Man, 1888) Postlarvae
(Terengganu: Universiti Malaysia Terengganu, 2015-05) Muhammad Hafiz Bahar
This study was conducted to differentiate the sexual characteristics and also to identify the ages when the sexes of banana shrimp, Fenneropenaeus merguiensis postlarvae (PL) can be differentiated. This study was also conducted to determine the effects of different low concentrations (0, 200, 400, 600, 800 and 1000 mg/kg) of estrogen hormone, 17B-estradiol (E2) on the survival, growth and feminization of F. merguiensis PL.
Effect of metal oxides on the releasing of nutrient ions from phosphate glass fertilizer system
(Terengganu: Universiti Malaysia Terengganu, 2016-07) Siti Hafizah Mohamad @ Md Hussin
Nowadays, the study of phosphate glass as potential glass fertilizer has been widely conducted due to the environmental consciousness of using chemical fertilizer that caused soil acidulation and water pollution.
Effect of salinity stress on carbohydrate metabolism in cryptocoryne elliptica cultures
(Terengganu: Universiti Malaysia Terengganu, 2013-12) Azmi Ismun
Salt condition could disturb water availability in plants which causes growth disturbance and also death. The plant regulates the stress by altering sugar content at metabolism level to survive the stress. This study was carried-out to determine the effects of different NaC1 concentrations - 100mM and 200mM/L - on carbohydrate metabolism in aquatic plant, Cryptocoryne elliptica cultures, as a model plant, for 35 days. The aquatic habitats represent stressful environments which are characterized for example by low carbon availability, uncertained availability of nutrient and shaded conditions induce plants to adapt with the environment on its fully potentials. Limited studies of aquatic plants also encouraged the study to be done. The salinity treatments were also carried-out in two different medium conditions: sucrose-contained- and sucrose-free medium. In this study, the accumulation of biomass, starch content and reducing sugar content were determined.
The effects of coper, leed and mercury treatments on physiological and biochemistry properties of five marine macroalgae
(Terengganu: Universiti Malaysia Terengganu, 2015-04) Luqman Abu Bakar
Heavy metals contaminating water bodies always be world’s concern and searching for the method to remove it started few decades back. Methods to reduce and remove heavy metals from aquatic environment ranging from physical, chemical and biological methods. In this study, the use of marine macroalgae is to obtain knowledge and information on the ability to be a biomarker of heavy metals pollution.
Establishment Of Tissue Culture Technique Towards Transformation Of Oryza Sativa With Omega-3 Desaturase Gene
(Universiti Malaysia Terengganu, 2017) Muhammad Haziq Syahir Bin Khaizuran
Salinity stress in paddy field had retarded the annual rice productivity influenced by ionic imbalance, physiological damage and biochemical breakdown. Few reports had categorized rice as a salt sensitive crop manifested in slow vegetative growth rate and delayed reproductive stage. In parallel towards high rice market demands, the establishment of new rice variety with high tolerance towards salt is important to overcome the tragic rice agriculture lost due to soil problems. The opening of newly paddy arable land is impossible due to urbanization. Instead of an exploitation of plant genetic sources in conventional crop breeding, advances in molecular breeding should be priority due wider genetic materials. Omega-3-Fatty Acid Desaturase (ω3-FAD) gene from marine microalgae Chorella Vulgaris strain UMT-M1 was employed in this study as a desired insert as the gene clustered as a saline-combat regulator. An initiative in this new variety production require the optimization of powerful tissue culture protocol.
Experimental and theoretical studies on the effects of fatty acids on the performance of antioxidants in inhibiting the oxidation of selected vegetable oils
(Terengganu: Universiti Malaysia Terengganu, 2014-11) Siti Balqis Che Othman
The aim of this research project was to study the effects of fatty acids on the performance of synthetic antioxidants in inhibiting the autoxidation of selected vegetable oils. In this study, four types of chain-breaking radical scavengers, BHA, BHT, TBHQ and PG, were utilized to test their performances, experimentally and theoretically in the presence or in the absence of fatty acids. Four types of fatty acids, PA, SA, OA and LA were added at several concentrations ranging from 0.25% w/w to 3.0% w/w.
Extracts of sponge-derived fungi as potential anti-atherosclerotic agent
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Nurul Faziana Kamal
Current drugs in the market for atherosclerosis mostly involved the reduction of atherosclerotic progression by decreasing the plasma low density lipoprotein (LDL) levels. With prolonged use of this drug, it is reported to may cause liver failure. Meanwhile, drugs targeting on high density lipoprotein (HDL) in reducing/preventing the development of atherosclerosis are yet to be developed, although HDL plays an important role in reverse cholesterol transport (RCT). Potential targets in RCT have been identified to prevent atherosclerosis: scavenger receptor class B type 1 (SR-B1) and peroxisome proliferator response elements (PPRE). This study was therefore carried-out to explore new peroxisome proliferator activated receptor (PPAR) ligand agonists for the activation of these potential targets, from sponge-derived fungi, as potential drugs for atherosclerosis.
Extracts of sponge-derived fungi as potential anti-atherosclerotic agent
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Nurul Faziana Kamal
Current drugs in the market for atherosclerosis mostly involved the reduction of atherosclerotic progression by decreasing the plasma low density lipoprotein (LDL) levels. With prolonged use of this drug, it is reported to may cause liver failure. Meanwhile, drugs targeting on high density lipoprotein (HDL) in reducing/preventing the development of atherosclerosis are yet to be developed, although HDL plays an important role in reverse cholesterol transport (RCT).
Hydrogel bio-composite based on gellan gum with modified montmorillonite for tissue engineering applications
(Terengganu: Universiti Malaysia Terengganu, 2016-03) Saffawati Syazwani Binti Mohd
This research focused on the study of physical, chemical and mechanical characteristics, cell studies and antibacterial properties of gellan gum (GG) hydrogel incorporated montmorillonite (MMT) fillers.

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