Pusat Pengajian Sains Asas

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Characterization of target-site mutation in 5-Enolpyruvylshikimate-3-Phosphate Synthase (EPSPS) gene from glyphosate-resistant biotype of Eleusine indica (L.) gaertn from Malaysia
(Terengganu: Universiti Malaysia Terengganu, 2013-06) Franci Julop
The population of goosegrass (Eleusine indica), resistant to glyphosate (an EPSPS–inhibiting herbicide) was found widespread in several states in Malaysia. However, the resistance levels in this plants which could lead to the understanding of its resistance mechanisms are not well studied. This study was therefore carried out to investigate different levels of resistance of goosegrass to glyphosate by the identification of mutations in the EPSPS gene. Whole plant bioassay confirmed that 9 out of the 20 populations collected were resistant, six populations were susceptible, while five populations were a mixture of resistant and susceptible biotypes.
Extracts of sponge-derived fungi as potential anti-atherosclerotic agent
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Nurul Faziana Kamal
Current drugs in the market for atherosclerosis mostly involved the reduction of atherosclerotic progression by decreasing the plasma low density lipoprotein (LDL) levels. With prolonged use of this drug, it is reported to may cause liver failure. Meanwhile, drugs targeting on high density lipoprotein (HDL) in reducing/preventing the development of atherosclerosis are yet to be developed, although HDL plays an important role in reverse cholesterol transport (RCT). Potential targets in RCT have been identified to prevent atherosclerosis: scavenger receptor class B type 1 (SR-B1) and peroxisome proliferator response elements (PPRE). This study was therefore carried-out to explore new peroxisome proliferator activated receptor (PPAR) ligand agonists for the activation of these potential targets, from sponge-derived fungi, as potential drugs for atherosclerosis.
Cytotoxicity, genotoxicity and quatitative structure-activity relationship (QSAR) studies of stnthesized carbonyl thiourea derivatives on acanthamoeba SPP. and human corneal epithelial cel
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Maizatul Akma Ibrahim
Forty-four synthesized carbonyl thiourea derivatives were evaluated for their potential as anti-amoebic agent, aiming for a new discovery in Acanthamoeba keratitis treatment. The compounds were tested on four isolates of Acanthamoeba namely A. castellanii (CCAP 1501/2A), A. polyphaga (CCAP 1501/3A), Acanthamoeba sp. (Hospital Kuala Lumpur isolate) and Acanthamoeba sp. (Setiu Wetland isolate).
Extracts of sponge-derived fungi as potential anti-atherosclerotic agent
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Nurul Faziana Kamal
Current drugs in the market for atherosclerosis mostly involved the reduction of atherosclerotic progression by decreasing the plasma low density lipoprotein (LDL) levels. With prolonged use of this drug, it is reported to may cause liver failure. Meanwhile, drugs targeting on high density lipoprotein (HDL) in reducing/preventing the development of atherosclerosis are yet to be developed, although HDL plays an important role in reverse cholesterol transport (RCT).
Effect of salinity stress on carbohydrate metabolism in cryptocoryne elliptica cultures
(Terengganu: Universiti Malaysia Terengganu, 2013-12) Azmi Ismun
Salt condition could disturb water availability in plants which causes growth disturbance and also death. The plant regulates the stress by altering sugar content at metabolism level to survive the stress. This study was carried-out to determine the effects of different NaC1 concentrations - 100mM and 200mM/L - on carbohydrate metabolism in aquatic plant, Cryptocoryne elliptica cultures, as a model plant, for 35 days. The aquatic habitats represent stressful environments which are characterized for example by low carbon availability, uncertained availability of nutrient and shaded conditions induce plants to adapt with the environment on its fully potentials. Limited studies of aquatic plants also encouraged the study to be done. The salinity treatments were also carried-out in two different medium conditions: sucrose-contained- and sucrose-free medium. In this study, the accumulation of biomass, starch content and reducing sugar content were determined.
Synthesis and characterisation of ferrocenyl-azobenzene derivatives for the development of diodes
(Terengganu: Universiti Malaysia Terengganu, 2013-12) Siti Athirah Mohamad Jamali
Photochromic azobenzene derivatives have attracted much attention recently due to their potential applications in the electronic and photonic devices. Introduction of a redox active unit to the azobenzene derivatives provides the opportunity for charge separation in the excited state of the systems. In this study, two series of ferrocenylazobenzene derivatives were synthesised.
Cultured marine bacteria isolated from sponges for discovery of bioactive compounds
(Terengganu: Universiti Malaysia Terengganu, 2014) Humairah Mohd Nasir
Association of marine bacteria and sponges was vastly reported since decades ago. Their contribution in the discovery of new bioactive compounds is also not a new issue. Interestingly, structural similarities between the metabolites of the sponge and its associated bacteria, those found within its tissue, indicate that these compounds are of bacterial origin. This study was conducted to isolate and characterize bacteria from marine sponges and to investigate the release of antibacterial compounds from marine isolates under ecologically relevant conditions.
Synthesis, characterization and antibacterial study of aaptamine derivatives
(Terengganu: Universiti Malaysia Terengganu, 2014-03) Fatin Nur Ain Abdul Rashid
Aaptamine is a bioactive marine alkaloid containing a unique 1H-benzo[de][ 1,6]naphthyridine skeleton. The remarkable biological activities displayed by aaptamine and its congeners have prompted many researchers to explore this group of compound. In this study, aaptamine was successfully isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications.
Synthesis, characterization and electrical conductivity studies of naphthoyl-thiourea derivatives as potential organic light emitting diode
(Terengganu: Universiti Malaysia Terengganu, 2014-05) Siti Maryam Jasman
Thiourea motif has attracted considerably great interest in numerous applications. Molecular framework featuring thiourea derivatives as molecular wire consists of conjugated systems which promises wide range of electronic properties and suitable to be applied in molecular electronics application.
Synthesis, Characterization And Electrical Conductivity Studies Of Naphthoyl-Thiourea Derivatives As Potential Organic Light Emitting Diode
(Universiti Malaysia Terengganu, 2014-05) Siti Maryam Binti Jasman
Thiourea motif has attracted considerably great interest in numerous applications. Molecular framework featuring thiourea derivatives as molecular wire consists of conjugated systems which promises wide range of electronic properties and suitable to be applied in molecular electronics application. Regarding to this matter, this study was carried out to determine the electrical conductivity and performance as OLED of this linear conjugated organic compounds with general formula A-ArC(O)NHC(S)NHAr-D. All synthesized compounds (1-5) were spectroscopically and analytically characterized via CHNS Elemental Microanalysis, Fourier Transform Infrared (FTIR), UltravioletVisible Spectroscopy (UV-Vis), Ultraviolet-Fluorescence Spectroscopy (UV-F), 1 H and 13 C Nuclear Magnetic Resonance (NMR), Single Crystal X-Ray Crystallography Analysis, X-Ray Diffraction Spectroscopy (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Cyclic Voltammetry (CV) Analysis. The compounds were fabricated on ITO substrate by using electrochemical deposition method (ECD) before the electrical conductivity and performances as OLED were tested by using Four Point Probe and Two Point Probe. The Gaussian 09 Software was used to calculate the energy band gap and the electrical conductivity of the synthesized compounds to compare with experimental evaluation. The infrared spectra for 1-5 showed five and six significant absorptions within the expected range. From UV-Vis spectra, they show the presence of -* and n-* electronic transitions which referred to C=O and C=S chromophores whereas from UV-F spectra, the emission spectra were observed for 1-5. The 1 H NMR spectra exhibit all expected resonances especially for δH 13 (NH). Whilst, C NMR spectra also show expected resonances of δC (C=O) and δC (C=S) to indicate that these compounds indeed thiourea derivatives. In addition, the energy bandgaps (Eg) of all synthesized compound were measured and confirmed by theoretical calculation. The energy bandgaps (Eg) of these compounds were at around 4.49-4.72 eV and it is in a good agreement with the theoretical calculation. From the electrical conductivity study, these compounds fall in the range of semiconductor materials which is 1.61x10 -4 -4 -1 -1.72x10 Scm under dark condition.
Development of carboxymethyl cellulose based proton conducting biopolymer electrolytes and its application in solid-state proton battery
(Terengganu: Universiti Malaysia Terengganu, 2014-06) Ahmad Salihin Samsudin
The chronicle in the field of alternative energy for energy storage has shown an excellent progress for the past few years. The increasing interest in green energy storage materials with the development of polymer or biopolymer as electrolytes candidate has attracted great attention.
Synthesis and characterization of alkoxy substituted thiourea with Curcuma longa as active layer in organic solar cell
(Terengganu: Universiti Malaysia Terengganu, 2014-07) Rafizah Rahamathullah
Organic solar cells based on single molecular system have attracted considerable attention because of their great potential to convert solar energy into electrical energy efficiently at low cost.
Characterization and mechanistic studies on the synthesis of 1,3,4-thiadiazole derivatives
(Terengganu: Universiti Malaysia Terengganu, 2014-08) Siti Fatimah Abdul Mutalib
The versatile compound of thiourea and a highly biological potential of Sbenzyldithiocarbazate (SBDTC) compound have inspired the production of hybrid compounds which contained both moieties which are thiourea and dithiocarbazate. For this reason, a reaction between acyl chloride, ammonium thiocyanate and SBDTC were reacted to produce the desired thiourea-dithiocarbazate derivatives. However, the desired compound did not obtained from the reaction but gives a heterocyclic compound namely 1,3,4-thiadiazole derivatives.
Synthesis, characterization and theorretical evaluation of phydylacyl thiourea derivatives as chemosensores for copper (ii) ion
(Terengganu: Universiti Malaysia Terengganu, 2014-09) Mohd Faizuddi Abu Hasan
Recently, there are a lot of researches dealing with the development of chemosensor for toxic metal detection in water system. Molecular framework of thiourea was previously reported to possess active chelating sites, electronic conjugated system and ease of synthetic approach which opens possibility for this type of moiety to be applied as chemosensor for metal ion detection.
Experimental and theoretical studies on the effects of fatty acids on the performance of antioxidants in inhibiting the oxidation of selected vegetable oils
(Terengganu: Universiti Malaysia Terengganu, 2014-11) Siti Balqis Che Othman
The aim of this research project was to study the effects of fatty acids on the performance of synthetic antioxidants in inhibiting the autoxidation of selected vegetable oils. In this study, four types of chain-breaking radical scavengers, BHA, BHT, TBHQ and PG, were utilized to test their performances, experimentally and theoretically in the presence or in the absence of fatty acids. Four types of fatty acids, PA, SA, OA and LA were added at several concentrations ranging from 0.25% w/w to 3.0% w/w.
Preparation of Mn3O4 based nanostructured compound via basic molten salf method as anode materials for lithium ion battery
(Terengganu: Universiti Malaysia Terengganu, 2015) Khairunnisa Haris
A novel crystalline nanostructured Mn3O4 was successfully synthesized using basic molten salt technique at 300°C, with a commercial MnCl2·2H2O as structuring agent. The formation, structure and morphology of Mn3O4 nanopowder were confirmed by thermo-gravimetric analysis (TGA), X-ray Diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDS). The TGA result revealed that the composite is formed at a low temperature of 300°C. The synthesized composite structure is a mixture of tetragonal (Mn3O4) and orthorhombic (MnO2) phases.
Inactivated form of hemocyanin subunit from Malaysian horseshoe crab tachypleus gigas as potential antimicrobial agent
(Terengganu: Universiti Malaysia Terengganu, 2015-02) James Jam Jolly
Hemocyanin is abundantly found in the hemolymph of the horseshoe crab Tachypleus gigas. Its vital roles are to serve as an oxygen transporter and defensive protein. However, it is believed that inactivated form of hemocyanin has antimicrobial properties as does its analogue, phenoloxidase. Therefore, this research was carried out to compare the antimicrobial response towards the hemocyanin in inactivated form and activated hemocyanin (phenoloxidase).
Synthesis and characterization of manganese oxide based materials as negative electrodes for lithium ion batteries
(Terengganu: Universiti Malaysia Terengganu, 2015-04) Syahidah Haniyah Mohammad
This thesis is written with the aim of exploring and investigating several types of materials with a particular focus on the microstructures, morphology and their electrochemical properties. The concept of integration two types of transition metal oxides (Mn3O4, Fe2O3) have been implemented due to several advantages which makes it a promising compound to be applied in the lithium (Li) ion battery.
The effects of coper, leed and mercury treatments on physiological and biochemistry properties of five marine macroalgae
(Terengganu: Universiti Malaysia Terengganu, 2015-04) Luqman Abu Bakar
Heavy metals contaminating water bodies always be world’s concern and searching for the method to remove it started few decades back. Methods to reduce and remove heavy metals from aquatic environment ranging from physical, chemical and biological methods. In this study, the use of marine macroalgae is to obtain knowledge and information on the ability to be a biomarker of heavy metals pollution.
Effect of estrogen hormone, 17 B-Estradiol on feminization, survival and growth of banana shrimp, Fenneropenaeus merguiensis (De Man, 1888) Postlarvae
(Terengganu: Universiti Malaysia Terengganu, 2015-05) Muhammad Hafiz Bahar
This study was conducted to differentiate the sexual characteristics and also to identify the ages when the sexes of banana shrimp, Fenneropenaeus merguiensis postlarvae (PL) can be differentiated. This study was also conducted to determine the effects of different low concentrations (0, 200, 400, 600, 800 and 1000 mg/kg) of estrogen hormone, 17B-estradiol (E2) on the survival, growth and feminization of F. merguiensis PL.

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