Fakulti Sains dan Teknologi

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Browsing Fakulti Sains dan Teknologi by Subject "Acanthamoeba"

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    Cytotoxic and genotoxic effects of methanolic crude extracts from selected marine sponges collected from Terengganu Island on Acanthamoeba SPP
    (Fakulti Sains dan Teknologi, 2008-05) Ida Muryany Md Yasin
    Acanthamoeba is a free-living amoeba but pathogenic to humans, causing a potentially blinding infection of the cornea(keratitis). Keratitis is an important public health problem developing country. Therefore, research on new drugs for the treatment of this infection is still constitutes an important therapeutic demand. The objective of this study were determined the cytotoxic and genotoxic effects of crude extracts of sponges from Aaptos sp., Xestospongia sp. and Halicondria sp. collected from Kapas, Perhentian and Redang Islands, Terengganu on trophozoites of two clinical isolates namely Acanthamoeba castellanii (IMR isolate) and Acanthamoeba sp. (HKL isolate) and one free-living amoeba, Acanthamoeba polyphaga strain 1501/3A (but potential of being pathogenic).
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    Molecular characterization of local isolates of acanthamoeba spp.
    (Fakulti Sains dan Teknologi, 2006-11) Siti Ruhaya Abdul Manaf
    The genus of Acanthamoeba comprises several species of amoebae and they are found in various habitats. Although free-living, these amoebae can infect humans and a variety of mammals and may invade brain, eyes, skin, bones and lungs. The taxonomy and classification of Acanthamoeba is still unclear and under review. Although, the genus Acanthamoeba can easily be classified by observing their morphological characteristics, but to differentiate the species of this organism proved to be more difficult. Therefore, other new, refined and reliable techniques such as biochemical and molecular approaches should also be incorporated to resolve its taxonomy and classification problems.