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Cytotoxicity, genotoxicity and quatitative structure-activity relationship (QSAR) studies of stnthesized carbonyl thiourea derivatives on acanthamoeba SPP. and human corneal epithelial cel
(Terengganu: Universiti Malaysia Terengganu, 2013-10) Maizatul Akma Ibrahim
Forty-four synthesized carbonyl thiourea derivatives were evaluated for their potential as anti-amoebic agent, aiming for a new discovery in Acanthamoeba keratitis treatment. The compounds were tested on four isolates of Acanthamoeba namely A. castellanii (CCAP 1501/2A), A. polyphaga (CCAP 1501/3A), Acanthamoeba sp. (Hospital Kuala Lumpur isolate) and Acanthamoeba sp. (Setiu Wetland isolate).