A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

dc.contributor.author	Laili Che Rose
dc.contributor.author	Joseph C. Bear
dc.contributor.author	Paul D. McNaughter
dc.contributor.author	Paul Southern
dc.date.accessioned	2017-04-09T08:54:20Z
dc.date.available	2017-04-09T08:54:20Z
dc.date.issued	2016-02-04
dc.description.abstract	An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/ wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/5506
dc.language.iso	en	en_US
dc.publisher	Scientific Reports	en_US
dc.title	A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia	en_US
dc.type	Article	en_US

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