A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia
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Date
2016-02-04
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Reports
Abstract
An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract
is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and
physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/
wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is
synthesised using a simple dip-coating process from pharmaceutically approved materials using a
gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions
within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field
under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and
inexpensive nature of our system demonstrated herein are key for successful drug delivery systems