Synthesis, Spectroscopic Studies, and Biological Activities of Acylthiourea Derivatives as Potential Anti-Bacteria Agents
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Educatum JSMT
Abstract
Thiourea is known to be a unique class of organic compounds especially acylthiourea since they consist excellent Hbonds
donor and acceptor where it has strong ability to form metal complexation with various metal salts. Therefore,
six members of acylthiourea derivatives (TH1-TH6) have been successfully synthesized and characterised using
selected spectroscopic and analytical methods namely Fourier-Transform Infrared (FT-IR) spectroscopy, UV-visible
(UV-vis) spectrophotometer, and CHNS elemental analysis. In turn, all the synthesised TH1-TH6 were used to
investigate the anti-bacterial activity towards selected bacteria of both Gram-negative and positive namely Salmonella
typhi and Bacillus cereus respectively. TH1-TH6 revealed to have good activity towards S. typhi and B. cereus with
specific and broad-range spectrum activity.
Description
Keywords
Thiourea, Spectroscopic, Antibacterial, Synthesis, Characterisation
Citation
Vol. 3 (1) ; 13-19 p.