Antibacterial properties of eight synthentic thiourea derivate compounds

Simple item page
dc.contributor.authorNurul Fakriah Che Hashim
dc.date.accessioned2018-11-21T07:21:59Z
dc.date.available2018-11-21T07:21:59Z
dc.date.issued2012
dc.description.abstractThe importance of antibacterial to human health and hygiene has led intense research in biological activities of thiourea derivatives at large scale. Thiourea derivative compounds are synthetic elements. Their molecular structures are similar as urea except the oxygen is replaced by sulfur. Previous study showed that these compounds exhibit a wide spectrum of biological activities such as anti-amoeba, antifungi, antibacterial and anticancer. Thus, this study was conducted to explore the antibacterial properties of eight thiourea derivative compounds against four common pathogenic bacteria. Each compound with five different concentrations; 200 μg/ml, 100 μg/ml, 50 μg/ml, 25 μg/ml and 12.5 μg/ml were tested on three gram-negative bacteria; Pseudomonas aeruginosa, Escheria coli, Proteus sp. and one gram-positive bacteria; Staphylococcus aureus. All eights synthetic thiourea derivative compounds showed antibacterial activity towards Staphylococcus aureus at MIC value of 12.5 μg/ml while other gram-negative bacteria were not affected by the compounds. The morphology of affected bacteria, when observed under Scanning Electron Microscopy showed several abnormal appearances of the cell morphology including raptured of cell wall of Staphylococcus aureus. This study suggests that synthetic thiourea derivative compounds had different effect towards gram-positive and gram-negative bacteria due to their different in the cell wall structure and outer membrane and also the properties of the synthetic thiourea derivative compound itself.en_US
dc.identifier.urihttps://umt-ir.umt.edu.my/xmlui/handle/123456789/10381
dc.language.isoenen_US
dc.publisherTerengganu: Universiti Malaysia Terengganuen_US
dc.subjectLP 6 FST 1 2012en_US
dc.subjectNurul Fakriah Che Hashimen_US
dc.titleAntibacterial properties of eight synthentic thiourea derivate compoundsen_US
dc.typeWorking Paperen_US
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
LP 6 FST 1 2012 Abstract.pdf
Size:
415 KB
Format:
Adobe Portable Document Format
Description:
Download
No Thumbnail Available
Name:
LP 6 FST 1 2012 Full Text.pdf
Size:
4.66 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Fakulti Sains dan Teknologi