Synthesis and Spectroscopic Studies of Alkyl Substituted Thiourea Derivatives Towards the Selected Antibacterial Activities

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dc.contributor.authorWan M. Khairul
dc.contributor.authorSiti Aishah Suskri
dc.contributor.authorRafizah Rahamathullah
dc.contributor.authorNoraznawati Ismail
dc.date.accessioned2017-04-11T00:23:39Z
dc.date.available2017-04-11T00:23:39Z
dc.date.issued2016
dc.description.abstractIn this study, new members of alkyl substituted thiourea derivatives of (RC( O)NHC(S)NHCH2CH(CH3)NHC(S)NHC(O)-R) in which R represents alkyl group namely isobutyryl and pivaloyl were successfully synthesized for their antibacterial activities. The compounds were spectroscopically and analytically characterized via infrared (IR) spectroscopy, ultraviolet–visible (UV– vis) spectroscopy, CHNS elemental analysis as well melting point analysis. In turn, they were screened for antibacterial activity using selected bacteria namely, Micrococcus sp., Salmonella typhi, Aeromonas sp., Klebsiella pneumoniae, Bacillus cereus and also Escherichia coli. From the antibacterial test, all synthesized compounds were found to exhibit great potential results as antibacterial agents, except for 1 which did not show inhibition activity towards Klebsiella pneumoniae. Thus, these proposed molecular structures have given ideal indication to act as antibacterial agents which have utmost potential in pharmaceutical and medical industries in the near future.en_US
dc.identifier.citationVol. 3 (1) ;28-33 p.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5650
dc.language.isoenen_US
dc.publisherEducatum JSMTen_US
dc.subjectSpectroscopicen_US
dc.subjectIsobutyrylen_US
dc.subjectPivaloylen_US
dc.subjectAlkyl-thioureasen_US
dc.subjectAntibacterial agenten_US
dc.titleSynthesis and Spectroscopic Studies of Alkyl Substituted Thiourea Derivatives Towards the Selected Antibacterial Activitiesen_US
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