Synthesis and Spectroscopic Studies of Alkyl Substituted Thiourea Derivatives Towards the Selected Antibacterial Activities
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Educatum JSMT
Abstract
In this study, new members of alkyl substituted thiourea derivatives of (RC(
O)NHC(S)NHCH2CH(CH3)NHC(S)NHC(O)-R) in which R represents alkyl group namely isobutyryl
and pivaloyl were successfully synthesized for their antibacterial activities. The compounds were
spectroscopically and analytically characterized via infrared (IR) spectroscopy, ultraviolet–visible (UV–
vis) spectroscopy, CHNS elemental analysis as well melting point analysis. In turn, they were screened for
antibacterial activity using selected bacteria namely, Micrococcus sp., Salmonella typhi, Aeromonas sp.,
Klebsiella pneumoniae, Bacillus cereus and also Escherichia coli. From the antibacterial test, all
synthesized compounds were found to exhibit great potential results as antibacterial agents, except for 1
which did not show inhibition activity towards Klebsiella pneumoniae. Thus, these proposed molecular
structures have given ideal indication to act as antibacterial agents which have utmost potential in
pharmaceutical and medical industries in the near future.
Description
Keywords
Spectroscopic, Isobutyryl, Pivaloyl, Alkyl-thioureas, Antibacterial agent
Citation
Vol. 3 (1) ;28-33 p.