Browsing by Author "Laili Che Rose"

Now showing 1 - 3 of 3
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    Exploiting Fatty Acid-Polymer-Based Lauric Acid and Chitosan as Coating Material for Drug Encapsulation
    (Middle-East Journal of Scientific Research, 2016) Sabiqah Tuan Anuar; Patricia nellane Ithurayasamy; Laili Che Rose
    A hybrid of saturated fatty acid and natural polymer was exploited as a coating material to encapsulated drug. Thus in this research, both lauric acid (C12 fatty acid) and chitosan were used as coating formulation for drug release at two different pH (1.2 and 6.8). The combination of fatty acid and chitosan, a linear polysaccharide, provides a better control of the drug release by selectively releasing the encapsulated drug in the selected pH. Results from FTIR and SEM showed that lauric acid-chitosan capsule coating is proven to have a film forming capability and stability with a controlled drug release at the mimicking human colon area pH. Moreover, initial study using in-vitro dissolution method indicated their capability to form a membrane and protect the drug from degradation.
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    Exploiting nanoscale materials properties for controlled drug delivery systems
    (United Kingdom: University of East Anglia, 2013-10) Laili Che Rose
    The main objective of this work was to develop a novel drug delivery system exploiting special opportunities afforded by synthesis of nanoscale materials to be applied inside the colon. It must be robust enough to cope with the adverse conditions in the gastrointestinal tract (GI) and be able to reach and release "on demand" at the colon area at the right time.
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    A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia
    (Scientific Reports, 2016-02-04) Laili Che Rose; Joseph C. Bear; Paul D. McNaughter; Paul Southern
    An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/ wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems