Potential Anti-Atherosclerotic Compound Isolated from Acanthaster planci

Simple item page
dc.contributor.authorNurul Hazirah Mat Lazim
dc.contributor.authorAsnuzilawati Asari
dc.contributor.authorFaridah Mohamad
dc.contributor.authorTg. Muhammad TS
dc.contributor.authorNoraznawati Ismail
dc.contributor.authorAziz Ahmad
dc.contributor.authorMariam Taib
dc.contributor.authorHabsah Mohamad
dc.date.accessioned2017-04-09T08:23:06Z
dc.date.available2017-04-09T08:23:06Z
dc.date.issued2016
dc.description.abstractMethyl benzoate was isolated from the the outer layer of A. planci (APOL) and tested towards cytotoxicity to HepG2 cells and Luciferase assay. The compound was not toxic towards HepG2 cells with IC50 value of 150.71 ±11.31 μg/ml. Methyl benzoate was screened with PPRE promoter to determine its ability as PPAR ligand and expressed the target gene with maximum fold change of range 3.5 to 4.0 at concentration 0.78 μg/ml. The confirmation as PPARɤ ligand was carried out with SRB-1 promoter and the positive results were obtained. The compound showed optimum expression higher than positive control used at 3.12μg/ml with almost 5.0 fold change. In addition, expression of Luciferase genes was higher than positive control even at lower concentration 0.39 μg/ml. These results indicated that methyl benzoate from APOL have the potential as anti-atherosclerotic agent, might as well beneficial as pharmaceutical products to prevent atherosclerosis which should be further explored.en_US
dc.identifier.citationVol.7(1) ; 482-487 p.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5461
dc.language.isoenen_US
dc.publisherResearch Journal of Pharmaceutical, Biological and Chemical Sciencesen_US
dc.subjectMethyl benzoateen_US
dc.subjectAcanthaster plancien_US
dc.subjectSRB-1 promoteren_US
dc.subjectanti-atherosclerotic agenten_US
dc.titlePotential Anti-Atherosclerotic Compound Isolated from Acanthaster plancien_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
222-Potential Anti-Atherosclerotic Compound Isolated from Acanthaster planci..pdf
Size:
723.78 KB
Format:
Adobe Portable Document Format
Description:
Fulltext file
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections