THE POTENTIAL OF CAROTENOIDS FROM MARINE TROPICAL MICROALGAE IN THE HEALING PROCESS OF GASTRITIS

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dc.contributor.authorAHMAD SHAMSUDDIN AHMAD
dc.contributor.authorYONG JULIUS FU SIONG*
dc.contributor.authorDESY FITRYA SYAMSUMIR
dc.contributor.authorNOR ATIKAH MOHAMED ZIN
dc.contributor.authorSITI AISHA MOHD RADZI
dc.contributor.authorMURNI NUR ISLAMIAH KASSIM
dc.contributor.authorMOHD ARIFF MUZAMEL
dc.contributor.authorMOHD RIDZUAN YUSOF
dc.contributor.authorTHIRUKANTHAN CHANDRA SEGARAN
dc.date.accessioned2017-10-04T04:34:38Z
dc.date.available2017-10-04T04:34:38Z
dc.date.issued2015
dc.description.abstractCarotenoids which are important towards the biological activities are produced by all higher plants, some bacteria and algae. Marine microalgae can produce a variety of substances including carotenoids and it has a commercial interest as production of microalgae in controlled condition is affordable. Three species of marine microalgae; Chlorella sp., Dunaliella sp. and Isochrysis sp. were cultured and carotenoids were extracted for testing. The total carotenoid present in dry weight of Chlorella sp., Dunaliella sp. and Isochrysis sp. were 55.1%, 99.3% and 29.4% respectively. The carotenoids from the microalgae were tested for toxicity level against MCF7 cancer cells, with Chlorella sp., Dunaliella sp. and Isochrysis sp. showing IC50 value 0.25mg/ml, 0.3 mg/ml and 0.32 mg/ml from crude extract respectively. Antioxidant di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) scavenging activity were present in all the three types of microalgae. In-vivo gastritis studies on model mice showed healed result from Dunaliella sp. but not from Chlorella sp. and Isochrysis sp. From the three microalgae species, Dunaliella sp. has the highest ability to promote gastric healing as it contains antioxidant and antimicrobial properties.en_US
dc.identifier.issn18238556
dc.identifier.urihttp://hdl.handle.net/123456789/7053
dc.language.isoenen_US
dc.publisherJournal of Sustainability Science and Managementen_US
dc.subjectCarotenoiden_US
dc.subjectmicroalgaeen_US
dc.subjectHelicobactor pylorien_US
dc.subjectDunaliella sp.en_US
dc.subjectChlorella sp.en_US
dc.subjectIsochrysis sp.en_US
dc.titleTHE POTENTIAL OF CAROTENOIDS FROM MARINE TROPICAL MICROALGAE IN THE HEALING PROCESS OF GASTRITISen_US
dc.typeArticleen_US
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