Browsing by Author "Fatimah Hashim"
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Item Cytotoxicity and genotoxicity of mahanimbine and girinimbine, pure compounds from murraya koeniggi on acanthamoeba spp. and human corneal epithelial cell line(Fakulti Sains dan Teknologi, 2010-06) Fatimah HashimMahanimbine (MH) and girinimbine (GR) are two carbazole alkaloids isolated from a local plant species, Murraya koenigii of the Rutaceae family. Both compounds have been shown to have insecticidal, antimicrobial, antifungal and anticancer properties.Item Morphological analysis on the toxic effect of manganese on Acanthamoeba sp. isolated from Setiu Wetland, Terengganu(Procedia Environmental Science, 2015) Fatimah Hashim; Nur Athirah Abdul Rahman; Nakisah Mat AminManganese (Mn) is one of the common pollutants found in aquatic environment that are difficult to destroy and very persistent in the water body. Excessive levels of Mn in the aquatic environment have threatened some of the aquatic organisms including free-living Acanthamoeba sp. In this study, Mn was assessed for its cytotoxicity and genotoxicity on Acanthamoeba sp. isolated from Setiu Wetland, Terengganu. IC50 value of Mn obtained was 24 ppm while morphological observation indicates that Acanthamoeba sp. underwent apoptotic and necrotic mode of cell death after exposure to Mn for 24 hours at 30°C. This metal is also able to induce mild genotoxicity towards the DNA of Acanthamoeba sp.