Effect oral vaccination of killed Pasteurella multocida B:2 on gut-associated ltymphoid tissue (Galt) in white rats

Abstract

Pasteurella multocida B:2 is a microorganism causing respiratory disease in ruminant animals mainly cattle and water buffaloes. The hemorrhagic septicemia disease causes high fatality rate towards many livestock in Asia. Oral vaccination is a way to induce mucosa[ immunity in the host. The Gut-associated Lymphoid Tissue (GALT) in the gastrointestinal tract plays an important role in activating and inducing immune response towards the other mucosa[ site through oral vaccination. Secretary lgA will be produced to prevent cellular attachment of the antigen on host cell through activation of the immune response. The effectiveness of the oral vaccination was proven having significant different of (p< 0.05) between the control and the treatment group for the area of GALT and the number of lymphocytes using ANOV A Two-Factor with Replication. However, there was no significant different between the weeks (p>0.05) for both area of GALT and he number of lymphocytes due to the fact that the Pasteurella multocida B:2 is a microorganism which infect the lung. Migration of lymphocytes to the lung will allow the mucosa[ site in the lung to increase the immunity towards Pasteurella multocida B:2. Repeated doses of vaccine through oral administration are suggested to enable the individual obtaining sufficient immunity.