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http://umt-ir.umt.edu.my:8080/handle/123456789/5962
Title: | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
Authors: | W.S.H., Wan Zullkiplee, Mohd Ariff, M.A. Hussain, H. Khairul, W.M. Ngaini, Z. |
Keywords: | Amino acid Antibacterial activity Tris-thiourea |
Issue Date: | 2016 |
Publisher: | Phosphorus, Sulfur and Silicon and the Related Elements |
Citation: | Vol 911; Issue 10;1329-1333 p. |
Abstract: | A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR,1H and13C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline. © 2016 Taylor & Francis Group, LLC. |
URI: | http://hdl.handle.net/123456789/5962 |
ISSN: | 1042 6507 |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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J2016-295-Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents.docx | Evidence | 91.66 kB | Microsoft Word XML | View/Open |
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