Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/5962
Title: Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents
Authors: W.S.H., Wan Zullkiplee,
Mohd Ariff, M.A.
Hussain, H.
Khairul, W.M.
Ngaini, Z.
Keywords: Amino acid
Antibacterial activity
Tris-thiourea
Issue Date: 2016
Publisher: Phosphorus, Sulfur and Silicon and the Related Elements
Citation: Vol 911; Issue 10;1329-1333 p.
Abstract: A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR,1H and13C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline. © 2016 Taylor & Francis Group, LLC.
URI: http://hdl.handle.net/123456789/5962
ISSN: 1042 6507
Appears in Collections:Journal Articles

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