Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/5960
Title: On-Demand, Magnetic Hyperthermia-Triggered Drug Delivery
Other Titles: Optimisation For The GI Tract
Authors: Laili, Che Rose
Joseph C., Bear
Paul, Southern
Paul D., McNaughter
R. Ben, Piggott
Ivan P., Parkin
Sheng, Qi
Brian P., Hills
Andrew G., Mayes
Keywords: Coatings
Magnetism
Vehicles Dip-coating process
Drug delivery system
Drug delivery vehicles
Iron oxide nanoparticle
Issue Date: 2016
Publisher: Journal of Materials Chemistry B
Citation: Vol 4; Issue 9;1704-1711 p.
Abstract: An orally-administered vehicle for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high incidence of diseases of that organ system and harsh mechanical and physical conditions any such drug delivery vehicle has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating that protects the capsule contents from the highly variable chemical conditions of the GI tract. It can be triggered using magnetic hyperthermia initiated from an external AC magnetic field. The coating is produced from pharmaceutically approved materials and is applied using a simple dip-coating process using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions found within the GI tract, but is completely melted within two minutes of magnetically-induced heating under biologically-relevant conditions of temperature, pH, buffer and external field strength, allowing the delivery and dispersal of the capsule contents. The overall simplicity of action, durability and non-toxic and inexpensive nature of our drug delivery vehicle demonstrated herein are key for successful drug delivery systems for the kinds of focal therapy being sought for modern precision medicine.
URI: http://hdl.handle.net/123456789/5960
ISSN: 2050 7518
Appears in Collections:Journal Articles

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