Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/5506
Title: A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia
Authors: Laili Che Rose
Joseph C. Bear
Paul D. McNaughter
Paul Southern
Issue Date: 4-Feb-2016
Publisher: Scientific Reports
Abstract: An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/ wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems
URI: http://hdl.handle.net/123456789/5506
Appears in Collections:Journal Articles



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