Preparation of Nanomaterials for Drug Delivery System via Microemulsion Polymerisation Method

Abstract

Microemulsion polymerisation method was employed in an initial attempt to prepare poly (alkylcyanoacrylate) nanomaterials. In this work,a region of water-in-oil microemulsion stabilised by non-ionic surfactant was identified and used as a templatefor the preparation of poly (alkylcyanoacrylate) nanomaterial. The non-ionic surfactants used were polyoxyetehylene (20) sorbitan monooleate (Tween 80) and Sorbitan monolaurate (Span 20). Monomers were added into the microemulsion template in order to obtain nanomaterial. The key physical properties of the materials were characterized employing standard techniques such as HPLC, FTIR, DLS, SEM and the in vitro release of insulin by dissolution method.