Please use this identifier to cite or link to this item: http://umt-ir.umt.edu.my:8080/handle/123456789/1653
Title: Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
Authors: Siti Nor Khadijah Addis
Keywords: QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
Issue Date: Nov-2011
Publisher: Australian national University
Series/Report no.: ;QP 609 .P78 S5 2011
Abstract: Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined.
URI: http://hdl.handle.net/123456789/1653
Appears in Collections:Staff Thesis

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