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Title: | Simultaneous dual syringe electrospinning system using benign solvent to fabricate nanofibrous P(3HB-co-4HB)/collagen peptides construct as potential leave-on wound dressing. |
Authors: | Vigneswari S Murugaiyah V Kaur G Abdul Khalil HP Amirul AA |
Keywords: | Benign solvent Collagen peptides Electrospinning P(3HB-co-4HB) Wound dressing |
Issue Date: | 2016 |
Publisher: | Materials Science and Engineering C |
Citation: | Vol.66; 147-155 p. |
Abstract: | The main focus of this study is the incorporation of collagen peptides to fabricate P(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] nano-fiber construct to further enhance surface wettability and support cell growth while harbouring desired properties for biodegradable wound dressing. Simultaneous electrospinning of nanofiber P(3HB-co-4HB)/collagen peptides construct was carried out using dual syringe system. The wettability of the constructs increased with the increase in 4HB molar fraction from 20mol% 4HB [53.2°], P(3HB-co-35mol%4HB)[48.9°], P(3HB-co-50mol%4HB)[44.5°] and P(3HB-co-82mol%4HB) [37.7°]. In vitro study carried out using mouse fibroblast cells (L929) grown on nanofiber P(3HB-co-4HB)/collagen peptides construct showed an increase in cell proliferation. In vivo study using animal model (Sprague Dawley rats) showed that nanofibrous P(3HB-co-4HB)/collagen peptides construct had a significant effect on wound contractions with the highest percentage of wound closure of 79%. Hence, P(3HB-co-4HB)/collagen peptides construct suitable for wound dressing have been developed using nano-fabrication technique. |
URI: | http://hdl.handle.net/123456789/5756 |
ISSN: | 9284931 |
Appears in Collections: | Journal Articles |
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73-Simultaneous_dual_syringe_electrospinning_system_using_benign_solvent_to_fabricate_nanofibrous_P(3HB-co-4HB)_collagen_peptides_construct_as_potenti.png | Evidence | 159.06 kB | image/png | View/Open |
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