Synthesis, Spectroscopic Studies, and Biological Activities of Acylthiourea Derivatives as Potential Anti-Bacteria Agents

Abstract

Thiourea is known to be a unique class of organic compounds especially acylthiourea since they consist excellent Hbonds donor and acceptor where it has strong ability to form metal complexation with various metal salts. Therefore, six members of acylthiourea derivatives (TH1-TH6) have been successfully synthesized and characterised using selected spectroscopic and analytical methods namely Fourier-Transform Infrared (FT-IR) spectroscopy, UV-visible (UV-vis) spectrophotometer, and CHNS elemental analysis. In turn, all the synthesised TH1-TH6 were used to investigate the anti-bacterial activity towards selected bacteria of both Gram-negative and positive namely Salmonella typhi and Bacillus cereus respectively. TH1-TH6 revealed to have good activity towards S. typhi and B. cereus with specific and broad-range spectrum activity.