http://umt-ir.umt.edu.my:8080/handle/123456789/3189 2026-04-05T17:05:13Z http://umt-ir.umt.edu.my:8080/handle/123456789/21135 Title: ELUCIDATION OF POTENTIAL PROTEINS ASSOCIATED WITH Vibrio parahaemolyticus INFECTION IN WHITELEG SHRIMP, Penaeus vannamei USING HOST-PATHOGEN PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS Authors: NUR FATHIAH ROSILAN 2024-01-01T00:00:00Z http://umt-ir.umt.edu.my:8080/handle/123456789/16423 Title: SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS Authors: LIEW KEN MIN Abstract: Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene moiety directly or indirectly attached to an indole core at any possible position of substitution. A series of seven new ferrocene-indole molecules was synthesised, designed and their cytotoxicity were tested against cancer cell lines. The study concludes that ferrocene-indole with indole substituted at position 2 and 7 are more active in cytotoxicity compared to the others in the series. The employed synthesis method was a resemblance of Steglich Esterification, with EDC·HCl acted as coupling agent and DMAP as catalyst. A precursor molecule, ferrocenephenylenediamine was synthesised through EDC coupling. In addition, a series of ferrocenephenyldiamide-indole was synthesised using the mentioned precursor, with all six possible indoles substituted by the precursor. Characterisation of the compounds were accomplished by Nuclear Magnetic Resonance (NMR), Fourier-Transform Infrared Spectroscopy (FT-IR), CHN Elemental Analysis and Mass Spectroscopy (MS). Meanwhile, MTS Assay was chosen as a biological evaluation of the six ferrocene-indole hybrids. 2020-01-01T00:00:00Z http://umt-ir.umt.edu.my:8080/handle/123456789/14680 Title: Synthesis And Characterization Of Disubstituted Conjugated Ethynylated-Imine Derivatives As Potential Liquid Crystalline Materials Authors: Mohd Rashid, Nur Amirah Nabilah Abstract: A typical liquid crystalline material usually consists of rigid center, linker/bridge and flexible chain tail. By taking this in consideration, 15 novel compounds bearing ethynyl (C=C), imine (C=N) and alkoxy chain were introduced through condensation process of primary amines and aldehydes. This highly conjugated molecules with general formula of Donor-Ar(C=N)Ar(C=C)Ar(C=N)Ar-Donor are believed to exhibit liquid crystalline nature. All synthesized compounds were characterized spectroscopically and analytically via CHN Elemental Microanalysis, Fourier Transform Infrared (FTIR), Ultraviolet-Visible spectroscopy (UV-Vis), 'H and 'C Nuclear Magnetic Resonance (NMR), Thermogravimetric analysis (TGA). Scanning Electron Microscopy (SEM) and Cyclic voltammetry (CV) analysis. For liquid crystal study, Differential Scanning Calorimetry (DSC) and Polarized Optical Microscopy (POM) were carried out to give better understanding. The infrared spectra revealed the most significant bands of interest C=N and C=C at 161 7-1621 em'and 2201 -- 2209 cm' respectively which then were confirmed by the presence of C=N resonance around 8.31 -- 8.39 ppm and c 159.00 - 161.75 ppm in 'H and C NMR spectroscopies respectively. 2019-08-01T00:00:00Z http://umt-ir.umt.edu.my:8080/handle/123456789/14665 Title: Synthesis And Characterization Of Disubstituted Conjugated Ethynylated-Imine Derivatives As Potential Liquid Crystalline Materials Authors: Mohd Rashid, Nur Amirah Nabilah Abstract: A typical liquid crystalline material usually consists of rigid center, linker/bridge and flexible chain tail. By taking this in consideration, 15 novel compounds bearing ethynyl (C=C), imine (C=N) and alkoxy chain were introduced through condensation process of primary amines and aldehydes. This highly conjugated molecules with general formula of Donor-Ar(C=N)Ar(C=C)Ar(C=N)Ar-Donor are believed to exhibit liquid crystalline nature. All synthesized compounds were characterized spectroscopically and analytically via CHN Elemental Microanalysis, Fourier Transform Infrared (FTIR), Ultraviolet-Visible spectroscopy (UV-Vis), 'H and 'C Nuclear Magnetic Resonance (NMR), Thermogravimetric analysis (TGA). Scanning Electron Microscopy (SEM) and Cyclic voltammetry (CV) analysis. For liquid crystal study, Differential Scanning Calorimetry (DSC) and Polarized Optical Microscopy (POM) were carried out to give better understanding. The infrared spectra revealed the most significant bands of interest C=N and C=C at 161 7-1621 em'and 2201 -- 2209 cm' respectively which then were confirmed by the presence of C=N resonance around 8.31 -- 8.39 ppm and c 159.00 - 161.75 ppm in 'H and C NMR spectroscopies respectively. 2019-08-01T00:00:00Z